United sweat on Kagawa's fitness after midfielder misses Japan qualifier
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The midfielder suffered the knock in training on Monday and was ruled out of his country's match just an hour before kick-off.
Kagawa is now a doubt for United's clash with Wigan on Saturday and their Champions League opener against Galatasaray next Wednesday.
United boss Sir Alex Ferguson is already without Wayne Rooney who suffered a gash in his thigh against Fulham while Jonny Evans has yet to feature this season following ankle surgery.
But the 25-year-old was called upon by manager Michael O'Neill for Northern Ireland in their 2-0 defeat at Russia on Friday night.
Evans limped off at half-time, but went on to play the full 90 minutes with his ankle heavily strapped.
It was expected the defender would not feature against Luxembourg, but Evans is set to play through the pain barrier on Tuesday.